The (freely available) MIRDcalc internal dose calculation software has been developed as a community tool for calculating organ-level radiopharmaceutical dosimetry. The software enables biodistribution-to-dosimetry calculations using the MIRD schema and incorporates calculation-specific details for 333 isotopes (ICRP Publication 107) and a family of 12 ICRP reference phantoms with 81 source organs/regions and 43 target organ/regions and up to 5 spherical tumors.
More information can be found in the software manual.
FAQ
- MIRDcalc is freely available for download
- MIRDcalc is written/compiled in the Mircosoft Excel platform
- Features of MIRDcalc : error propagation, phantom interpolation, dynamic remainder values, quality control checks, documentation standardization, and optional command line execution
- Future versions are expected
Reference Publications
Kesner, AL, Carter LM, Ramos JCO, Lafontaine D, Olguin EA, Brown JL, President B, Jokisch DW, Fisher DR, Bolch WE. “MIRD Pamphlet No. 28, Part 1: MIRDcalc-A Software Tool for Medical Internal Radiation Dosimetry”, Journal Nuclear Medicine, 2023
https://pubmed.ncbi.nlm.nih.gov/37268428/
Carter LM, Ocampo Ramos JC, Olguin EA, Brown JL, Lafontaine D, Jokisch DW, Bolch WE, Kesner, A.L., “MIRD Pamphlet No. 28, Part 2: Comparative Evaluation of MIRDcalc Dosimetry Software Across a Compendium of Diagnostic Radiopharmaceuticals”. Journal of Nuclear Medicine, 2023.
https://pubmed.ncbi.nlm.nih.gov/37268423/
Documentation & Instruction Manuals
Document manual (version 1.1.0.0)
System Requirements
MIRDcalc is written and compiled within Microsoft Excel, and runs in the Excel environment. A licensed version of Microsoft Excel must be installed on the host computer.
Currently, MIRDcalc only works on a PC.
More information regarding system requirement can be found in the software manual.
Acknowledgements & Authors
The MIRDcalc software is a product of an ongoing collaboration between University of Florida, Gainesville, FL, USA and Memorial Sloan Kettering Cancer Center, New York, USA.
This research was part of a funded project support by the NIH U01 EB028234 grant.
Major contributors to this development of this software include:
Adam Kesner (MSKCC, co-PI)
Wesley Bolch (UF, co-PI)
Justin Brown (UF), Lukas Carter (MSKCC), Sean J. Domal (UF), John L. Humm (MSKCC), Derek Jokisch (FMU), Ryan Kerslake (MSKCC), Cameron B. Kofler (UF), Daniel Lafontaine (MSKCC), Harry Marquis (MSKCC), Juan C. Ocampo Ramos (MSKCC), Edmond Olguin (UF), Bonnie N. President (UF), Trung Tran (UF), Pat Zanzonico (MSKCC)
MIRDcalc User Message Board
MIRDcalc user notes