MIRDpvc

 

The (freely available) MIRDpvc MS Excel worksheet was developed to support standardized and accessible partial-volume correction (PVC) in quantitative PET and SPECT imaging. MIRDpvc implements both conventional and advanced recovery coefficient (RC)-based correction models, including the shape-specific RECOVER-GM method, which accounts for lesion geometry and system resolution to improve quantification accuracy. Users can calibrate the worksheet with phantom data or input system resolution, then select from multiple PVC models—RECOVER-GM, 2-parameter logistic (2-PL), and 3-parameter logistic (3-PL)—to correct for partial-volume losses. The tool accepts user inputs such as measured activity, background signal, volume, and shape parameters to compute corrected activity concentrations. Built in Microsoft Excel and designed for clarity and usability, MIRDpvc aims to promote best practices in PVC by integrating resolution modeling, model selection, and quality control in a single, easy-to-use interface. More information is provided in the software manual, supporting peer reviewed overview coming soon.

FAQ

• MIRDpvc is freely available for download
• MIRDpvc is written in the Microsoft Excel platform
• Features of MIRDpvc:
  • Implements RECOVER-GM for shape-specific partial-volume correction (PVC);
  • Supports 2-parameter and 3-parameter logistic recovery coefficient (RC) models;
  • Allows calibration with phantom-derived RCs or input of system resolution;
  • Enables correction of both spill-out and spill-in effects;
  • Accepts user-defined object dimensions, volumes, and background activity;
  • Single-screen, user-friendly interface with clear data inputs and outputs;
  • Provides immediate calculations with built-in quality control checks;
  • Open-source, transparent formulas and calculations for educational use.

Reference Publications

MIRDPVC THEORY

MIRD Pamphlet No. 32: A MIRD Recovery Coefficient Model for Resolution Characterization and Shape-Specific Partial-Volume Correction

Harry Marquis, C Ross Schmidtlein, Robin de Nijs, Pablo Mínguez Gabiña, Johan Gustafsson, Gunjan Kayal, Juan C Ocampo Ramos, Lukas M Carter, Dale L Bailey, Adam L Kesner
Journal of Nuclear Medicine March 2025
https://doi.org/10.2967/jnumed.124.268520

MIRDPVC SOFTWARE

MIRD Pamphlet No. 33: MIRDpvc—A Software Tool for Recovery Coefficient–Based Partial-Volume Correction

Documentation & Instruction Manuals

Document manual (version 1.0.0.0)

System Requirements

MIRDpvc is written and compiled within Microsoft Excel, and runs in the Excel environment. A licensed version of Microsoft Excel must be installed on the host computer. MIRDpvc is compatible with Microsoft Excel (PC & Mac) versions 2013 and later.

Acknowledgements & Authors

The MIRDpvc software is a product of an ongoing collaboration between Memorial Sloan Kettering Cancer Center, New York, USA; Lund University, Sweden; Copenhagen University Hospital, Denmark; BioBizkaia Health Research Institute, Spain; and Royal North Shore Hospital, Sydney, Australia. This research was supported in part by NIH grants U01 EB028234, R21 CA263876, R01 EB032416, and P30 CA008748. Major contributors to the development of this software include: Harry Marquis (MSKCC) (principal) Adam Kesner (MSKCC) Ross Schmidtlein (MSKCC) Gunjan Kayal (MSKCC) Juan C. Ocampo Ramos (MSKCC) Lukas M. Carter (MSKCC) Johan Gustafsson (Lund University) Robin de Nijs (Copenhagen University Hospital) Pablo Mínguez Gabiña (BioBizkaia Health Research Institute) Dale Bailey (Royal North Shore Hospital) A special thanks to the MIRD Committee of the SNMMI and collaborators who contributed to model development, validation studies, and community feedback.