MIRDcalc software use notes

MIRDcalc User Notes

⚠️ Please use MIRDcalc Version 1.21 or later

Earlier versions may contain a rare but possible calculation error (see v1.21 explanation below).

All other updates are mostly minor in nature. All versions are cross compatible, and we recommend users utilize the most up-to-date version, available at the download link on this website.

Installation Instructions

If you encounter issues installing MIRDcalc, fully uninstall any previous version before reinstalling.
To uninstall, use the uninstaller at:
C:\MIRDsoft\MIRDcalc\MIRDcalc_v1.0\unins000.exe
or go to Control Panel → Programs and Features → MIRDcalc.

Known Issues & Updates

🔐 Antivirus Compatibility

Trend Micro Antivirus (June 25, 2021)
Issue resolved: Trend Micro has whitelisted MIRDcalc as of June 24, 2021.
General Antivirus Issues (June 25, 2021)
All downloads from June 25, 2021, onward include a code-signing certificate. This reduces false antivirus flags. If you’re still experiencing issues, please contact us.

🌍 Regional Settings Bug (June 25, 2021)

Some users saw abnormal values (e.g., patient mass in thousands of kg) due to use of . as a thousands delimiter.
✅ Fixed in versions compiled after June 25, 2021.
🧪 A QC test is available to verify regional setting compatibility — See QC link here.

Version History

Version	Date	Details
v1.24	2025-05-28	Fixed an error in alpha dose uncertainty calculations. The radiation weighting factor was incorrectly included in absorbed dose uncertainty estimates, while it should only be included in effective dose and detriment weighted dose uncertainty calculations. Recompiled using updated 2025.0 compiler to improve compatibility.
v1.23	2025-01-07	Recompiled with updated compiler for improved system compatibility. Increased maximum allowable tumor volume to 1000 cc. Unscrambled S value database for transparency and research use (path: `C:\MIRDsoft\MIRDcalc\MIRDcalc_vx.xx\Lib\MCNM_DB`).
v1.22	2024-11-08	Updated organ weighting values for effective dose calculation per ICRP 133 Table 2.3. Changed whole-body dose calculation to use mass-weighted target region doses (impacts users who modify organ masses). Recompiled with modern compiler to support new integration features.
v1.21	2023-07-07	Fixed Excel function compatibility issue affecting European tumor dosimetry users. Critical fix version — all users should upgrade to at least this version. Resolved a database bug affecting mass switching between similar phantoms – the issue was in certain (albeit rare) situations an error in loading correct organ masses was possible. The new version ensures smooth/correct changes of phantoms database.
v1.2	2023-05-17	Updated self- and cross-dose definitions (minor impact on results; improves clarity). Added user-defined save location and shorter default filenames. Improved GUI layout and removed forced fullscreen behavior. Enhanced support for data import and added backend integrity checks.
v1.1	2022-03-09	Fixed interpolation bug where S values were incorrectly set to zero when nearby phantoms had identical assigned masses.

Troubleshooting Installation Error

❗ Error:

“IPersistFile Save failed, Code 0x80070005 – Access is denied”

This error typically indicates a permissions issue during installation. Try the following steps:

✅ Steps to Resolve:

Confirm Administrator Access
Ensure you are logged in as an administrator on your workstation.
Run Installer as Administrator
Right-click the installer and choose “Run as administrator.”
Temporarily Disable Antivirus Software
Disable your antivirus temporarily and retry installation. Re-enable afterward.
Check Folder Permissions
- Right-click the install folder → Properties → Security tab
- Ensure your user account has Write and Modify permissions
Choose a Different Installation Location
Try a folder like your Desktop or User folder.
Check Group Policies (Managed Devices)
If on a managed device, consult IT for system restrictions.
Restart Your Computer
A reboot may resolve temporary permission issues.

If the issue persists, contact the MIRDsoft support team for assistance.