MIRDsoft is proud to share links to the freely available SIGFRID Radiopharmaceutical Therapy (RPT) educational video series!
EFOMP SIGFRID Radiopharmaceutical Lecture Series
This collection of 24 videos walks through foundational concepts, clinical applications, and advanced techniques in nuclear medicine dosimetry. Topics span radiopharmaceutical modeling, activity quantification, absorbed dose algorithms, clinical workflows, and real-world treatment outcomes.
Presented by the EFOMP Special Interest Group for Radionuclide Internal Dosimetry (SIGFRID).
Explore the YouTube Playlist here. The freely available videos are also linked below:
Section A: Introduction to Dosimetry
- P1: Dosimetry politics – Katarina Sjögreen Gleisner
- P2: Definitions – Ernesto Amato
- P3: Nuclear medicine dosimetry formalism – Manuel Bardiès
Section B: Diagnostic vs Therapeutic Dosimetry
- P4: Concept of NM – Julia Brosch Lenz
- P5: Intro to ICRP and Model-based dosimetry – Silvano Gnesin
- P6: Differences in dosimetry – Carolinie Stokke
Section C: Activity Quantification Methods
- P7: WB Counting Methods – Jan Taprogge
- P8: Imaging I – Pablo Minguez
- P9: Imaging II – Pablo Minguez Imaging
Section D: Biokinetics and Time-Integrated Activity
- P10: Intro to pharmacokinetic modelling – Gerhard Glatting
- P11: Input data, integration methods – Deni Hardiansyah
- P12: Population-based methods – Deni Hardiansyah
Section E: Absorbed Dose Calculation Algorithms
- P13: Choosing the algorithm – Daniele Pistone
- P14: Examples of uses in clinical practice – Manuel Bardiès
- P15: Example of image-based dosimetry – Manuel Bardiès
Section F: Clinical Dosimetry Workflow
- P16: From activity measurement to the dosimetry report – Manuel Bardiès
- P17: Validation of CDW: step by step and from end-to-end – Manuel Bardiès
- P18: Traceability and uncertainties – Ana Denis-Bacelar
Section G: Dosimetry in Clinical Practice
- P19: WB Bone Marrow Dosimetry – Jan Taprogge
- P20: Image based dosimetry – Peters Steffie
- P21: SIRT planning and verification – Carlo Chiesa
Section H: Clinical Success of Dosimetry
- P22: 131I-based therapies (thyroid dose response) – Jan Taprogge
- P23: 177Lu-based therapies – Marta Cremonesi
- P24: SIRT dose effect – Carlo Chiesa
P1: A: Introduction to dosimetry: Dosimetry politics
Speaker: Katarina Sjögreen Gleisner
Keywords: dosimetry, policy, foundations
Explores the political and institutional considerations affecting routine dosimetry implementation.
P2: A: Introduction to dosimetry: Definitions
Speaker: Ernesto Amato
Keywords: absorbed dose, effective dose, definitions
Clarifies core concepts in dosimetry including absorbed dose, effective dose, and dose quantities.
P3: A: Introduction to dosimetry: Nuclear medicine dosimetry formalism
Speaker: Manuel Bardiès
Keywords: dosimetry formalism, MIRD schema
Introduces the mathematical and conceptual framework of dosimetry in nuclear medicine.
P4: B: Diagnostic vs therapeutic dosimetry: Concept of NM
Speaker: Julia Brosch Lenz
Keywords: therapy, diagnostics, nuclear medicine
Describes the diagnostic and therapeutic applications of radiopharmaceuticals.
P5: B: Diagnostic vs therapeutic dosimetry: Intro to ICRP and Model-based dosimetry
Speaker: Silvano Gnesin
Keywords: ICRP, reference models, biokinetics
Outlines ICRP models and their role in model-based dosimetry.
P6: B: Diagnostic vs therapeutic dosimetry: Differences in dosimetry
Speaker: Carolinie Stokke
Keywords: diagnostic dosimetry, therapeutic dosimetry
Highlights the clinical and technical differences in dosimetry approaches.
P7: C: Activity quantification methods: WB Counting Methods
Speaker: Jan Taprogge
Keywords: whole-body counting, quantification
Reviews whole-body counting techniques used in activity quantification.
P8: C: Activity quantification methods: Imaging I
Speaker: Pablo Minguez
Keywords: activity imaging, quantification
Explains foundational imaging techniques for activity quantification.
P9: C: Activity quantification methods: Imaging II
Speaker: Pablo Minguez Imaging
Keywords: SPECT, PET, image quantification
Continues from part I, covering image-based quantification with PET/SPECT.
P10: D: Biokinetics and time-integrated activity: Intro to pharmacokinetic modelling
Speaker: Gerhard Glatting
Keywords: pharmacokinetics, time-integrated activity
Introduces pharmacokinetic modeling in radiopharmaceutical biokinetics.
P11: D: Biokinetics and time-integrated activity: Input data, integration methods
Speaker: Deni Hardiansyah
Keywords: integration methods, input data
Covers practical methods to obtain and process input data for dosimetry.
P12: D: Biokinetics and time-integrated activity: Population-based methods
Speaker: Deni Hardiansyah
Keywords: population methods, variability
Explores population-based dosimetry approaches for estimating absorbed doses.
P13: E: Absorbed dose calculation algorithms: Choosing the algorithm
Speaker: Daniele Pistone
Keywords: absorbed dose, algorithm selection
Discusses how to select appropriate dose calculation algorithms in clinical contexts.
P14: E: Absorbed dose calculation algorithms: Examples of uses in clinical practice
Speaker: Manuel Bardiès
Keywords: clinical dosimetry, examples
Provides case-based examples of dose calculations in clinical workflows.
P15: E: Absorbed dose calculation algorithms: Example of image-based dosimetry
Speaker: Manuel Bardiès
Keywords: image-based dosimetry, workflow
Walkthrough of an image-based dosimetry scenario using real clinical data.
P16: F: Clinical dosimetry workflow: From activity measurement to the dosimetry report
Speaker: Manuel Bardiès
Keywords: dosimetry workflow, reporting
Presents an end-to-end overview of clinical dosimetry and structured reporting.
P17: F: Clinical dosimetry workflow: Validation of CDW: step by step and from end-to-end
Speaker: Manuel Bardiès
Keywords: validation, quality assurance
Explains how to validate a clinical dosimetry workflow both locally and globally.
P18: F: Clinical dosimetry workflow: Traceability and uncertainties
Speaker: Ana Denis-Bacelar
Keywords: uncertainty, traceability
Covers uncertainty sources and the importance of traceability in clinical dosimetry.
P19: G: Dosimetry in Nuclear Medicine Clinical Practice: WB Bone Marrow Dosimetry
Speaker: Jan Taprogge
Keywords: bone marrow, whole-body dosimetry
Focuses on bone marrow dosimetry using whole-body methods.
P20: G: Dosimetry in Nuclear Medicine Clinical Practice: Image based dosimetry
Speaker: Peters Steffie
Keywords: image-based, clinical dosimetry
Demonstrates real-world application of image-based dosimetry.
P21: G: Dosimetry in Nuclear Medicine Clinical Practice: SIRT planning and verification
Speaker: Carlo Chiesa
Keywords: SIRT, therapy planning
Details selective internal radiation therapy planning and verification.
P22: H: Clinical success of dosimetry: 131I-based therapies (thyroid dose response)
Speaker: Jan Taprogge
Keywords: I-131, thyroid, outcomes
Reviews clinical outcomes and dose response for I-131 therapy.
P23: H: Clinical success of dosimetry: 177Lu-based therapies
Speaker: Marta Cremonesi
Keywords: Lu-177, therapy outcomes
Shares successful case examples using Lu-177 therapies.
P24: H: Clinical success of dosimetry: SIRT dose effect
Speaker: Carlo Chiesa
Keywords: SIRT, dose-effect
Evaluates dose-response effect of SIRT using clinical evidence.
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